Senior Scientist, Medicinal Chemistry

Skeletalis is a Boston-based biotechnology company developing next-generation therapeutics to rebuild and protect the skeletal system. Our platform technology leverages bone-targeted small molecules for treatment of osteoporosis and other musculoskeletal diseases. Skeletalis is backed by Pillar, KdT, and age1 ventures.

We’re a small, science-driven, and fast-growing team looking for a Senior Scientist (Medicinal Chemistry) to lead our chemistry efforts as an individual-contributor consultant, with the potential to transition into a full-time role as the company scales.

What You’ll Do

• Lead medicinal chemistry strategy and execution — from hit-to-lead optimization to development candidate nomination
• Drive structure-based design, SAR exploration, synthetic route design, and multi-step synthesis
• Oversee route scouting, process development, and API delivery (mg → kg scale) for preclinical and CMC activities (non-GMP through cGMP)
• Manage CROs, CDMOs, and independent consultants to ensure scientific rigor, quality, and on-time delivery
• Coordinate chemistry logistics supporting downstream biology, formulation, and IND-enabling studies
• Contribute to IP strategy, due diligence, and preparation of scientific presentations and publications
• Expand the platform chemistry to generate new small-molecule and peptidomimetic assets

What You Bring

• PhD or MS in Organic or Medicinal Chemistry (or related discipline), with at least 5 years of industry experience.
• Proven experience leading small-molecule or peptidomimetic drug discovery programs
• Direct experience managing SAR campaigns and CRO/CDMO vendors
• Strong foundation in multi-step synthesis, route design, and process scale-up
• Excellent project management and communication skills

Nice to Have

• Tablet/capsule formulation or in-vitro ADME experience
• Familiarity with in-silico design tools and GMP manufacturing
• Exposure to IP licensing, due diligence, or publication development

Why Join Us

• Shape the chemistry and development strategy of a high-impact early-stage biotech
• Work directly with executive leadership in a fast-paced, collaborative, mission-driven culture
• Consultant role with opportunity for full-time hire and future leadership growth